Advances in polymer micro needle technology for transdermal medication administration
Abstract
By placing a medication plan into healthy, unblemished skin, the Transdermal Drug Delivery System (TDDS) is a simple method of delivering medications topically. The drug enters through the cuticle and then passes through the epidermis and dermis without entering the drug, primarily concentrating in the dermal layer. The use of microneedles for transdermal medicine delivery is becoming more and more popular due to problems associated with oral medication delivery methods. The medication's digestive tract exposes it to corrosive and catalytic substances found in the stomach, which causes the compound to denaturate and results in low bioavailability. This review focuses solely on the accessible literature from the past ten years in order to assess the various fabrication techniques, provide an update on the progress made in the creation of polymeric MNs, discuss the difficulties encountered in the process, and assess the potential uses of polymeric MNs in the healthcare industry. Microneedles are regarded as sturdy.
Keywords:
Skin, Transdermal route, Microneedle, Drug delivery system, Polymer microneedle
References
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https://www.sciencedirect.com/science/article/pii/S0927796X16300213
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13. Guillot AJ, Martínez‐Navarrete M, Zinchuk‐Mironova V, Melero A. Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2023 Jul;15(4):e1884
14. Kim KS, Ita K, Simon L. Modelling of dissolving microneedles for transdermal drug delivery: theoretical and experimental aspects. European Journal of Pharmaceutical Sciences. 2015 Feb 20;68:137-43.
15. . Yadav PR, Han T, Olatunji O, Pattanayek SK, Das DB. Mathematical modelling, simulation and optimisation of microneedles for transdermal drug delivery: trends and progress. Pharmaceutics. 2020 Jul 22;12(8):693.
16. Zhao X, Li X, Zhang P, Du J, Wang Y. Tip-loaded fast-dissolving microneedle patches for photodynamic therapy of subcutaneous tumor. Journal of controlled release. 2018 Sep 28;286:201-9.
17. Dathathri E, Lal S, Mittal M, Thakur G, De S. Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery. Applied Nanoscience. 2020 Feb;10:371-7.
18. Sabri AH, Kim Y, Marlow M, Scurr DJ, Segal J, Banga AK, Kagan L, Lee JB. Intradermal and transdermal drug delivery using microneedles–Fabrication, performance evaluation and application to lymphatic delivery. Advanced drug delivery reviews. 2020 Jan 1;153:195-215.
19. DASARI V, AWEN BZ, CHANDU BR, MUKKANTI K. Formulation and in vitro evaluation of Lamivudine multiunit floating dosage forms using novel lipoidal polymers. Int J Pharma Bio Sci. 2010;1(3):1-7.
20. Nanjwade BK, Bechra HM, Derkar GK, Manvi FV, Nanjwade VK. Dendrimers: emerging polymers for drug-delivery systems. European Journal of Pharmaceutical Sciences. 2009 Oct 8;38(3):185-96.
2. Zaid Alkilani A, McCrudden MT, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015 Oct 22;7(4):438-70. https://pubmed.ncbi.nlm.nih.gov/26506371/
3. McAllister DV. Microfabricated microneedles, A novel approach to transdermal drug delivery. InProceed. Int'1. Symp. Control. Release Bioact. Mater. 1998 (Vol. 25, pp. 30-31). https://pubmed.ncbi.nlm.nih.gov/9687334/
4. Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & pharmacotherapy. 2019 Jan 1;109:1249-58.
5. Shakya AK, Ingrole RS, Joshi G, Uddin MJ, Anvari S, Davis CM, Gill HS. Microneedles coated with peanut allergen enable desensitization of peanut sensitized mice. Journal of controlled release. 2019 Nov 28;314:38-47. https://pubmed.ncbi.nlm.nih.gov/31626861/
6. GP B, Desu PK, Rao CB. STAR POLYMERS: AN OVERVIEW. International Journal of Biological & Pharmaceutical Research.2013; 4(2): 76-79.
7. Chen B, Wei J, Iliescu C. Sonophoretic enhanced microneedles array (SEMA)—Improving the efficiency of transdermal drug delivery. Sensors and Actuators B: Chemical. 2010 Mar 4;145(1):54-60.
8. Larrañeta E, Lutton RE, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. 2016 Jun 1;104:1-32.
https://www.sciencedirect.com/science/article/pii/S0927796X16300213
9. Moore GK, Howell SE, Brady M, Xu X, McNeil K. Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice. Nature communications. 2021 Jan 4;12(1):1.
10. Hao Y, Li W, Zhou X, Yang F, Qian Z. Microneedles-based transdermal drug delivery systems: a review. Journal of biomedical nanotechnology. 2017 Dec 1;13(12):1581-97.
11. Parhi R. Review of microneedle based transdermal drug delivery systems. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2019 May 31;12(3):4511-23.
12. Duarah, S.; Sharma, M. (2019) Recent advances in microneedle-based drug delivery: Special emphasis on issues in paediatricpopulation. Eur. J. Pharm. Biopharm.
13. Guillot AJ, Martínez‐Navarrete M, Zinchuk‐Mironova V, Melero A. Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2023 Jul;15(4):e1884
14. Kim KS, Ita K, Simon L. Modelling of dissolving microneedles for transdermal drug delivery: theoretical and experimental aspects. European Journal of Pharmaceutical Sciences. 2015 Feb 20;68:137-43.
15. . Yadav PR, Han T, Olatunji O, Pattanayek SK, Das DB. Mathematical modelling, simulation and optimisation of microneedles for transdermal drug delivery: trends and progress. Pharmaceutics. 2020 Jul 22;12(8):693.
16. Zhao X, Li X, Zhang P, Du J, Wang Y. Tip-loaded fast-dissolving microneedle patches for photodynamic therapy of subcutaneous tumor. Journal of controlled release. 2018 Sep 28;286:201-9.
17. Dathathri E, Lal S, Mittal M, Thakur G, De S. Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery. Applied Nanoscience. 2020 Feb;10:371-7.
18. Sabri AH, Kim Y, Marlow M, Scurr DJ, Segal J, Banga AK, Kagan L, Lee JB. Intradermal and transdermal drug delivery using microneedles–Fabrication, performance evaluation and application to lymphatic delivery. Advanced drug delivery reviews. 2020 Jan 1;153:195-215.
19. DASARI V, AWEN BZ, CHANDU BR, MUKKANTI K. Formulation and in vitro evaluation of Lamivudine multiunit floating dosage forms using novel lipoidal polymers. Int J Pharma Bio Sci. 2010;1(3):1-7.
20. Nanjwade BK, Bechra HM, Derkar GK, Manvi FV, Nanjwade VK. Dendrimers: emerging polymers for drug-delivery systems. European Journal of Pharmaceutical Sciences. 2009 Oct 8;38(3):185-96.
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How to Cite
Balusupati, B., Balusupati, T., Budagala, G., & Chandu, B. R. (2024). Advances in polymer micro needle technology for transdermal medication administration. Journal of Integral Sciences, 7(1), 28-32. https://doi.org/10.37022/jis.v7i1.84
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