Formulation and evaluation of Naproxen sustained release matrix tablet

  • Kishore Naidu K AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India 530003
  • Lakshmana Rao R Department of Pharmaceutical Technology, MRR College of Pharmacy, Nandigama, Andhra Pradesh, India-521185
  • Pratap Kumar G Department of Pharmaceutical Technology, MRR College of Pharmacy, Nandigama, Andhra Pradesh, India-521185
  • Sathya S Priya A Department of Pharmaceutical Technology, MRR College of Pharmacy, Nandigama, Andhra Pradesh, India-521185


The present study was carried out to formulate sustained release matrix tablet of naproxen and to evaluate its drug release and stability. Formulation and evaluation of oral sustained release matrix tablets of naproxen were prepared by wet granulation technique by employing different concentration of HPMC-K4M, HPMC-K100 and DCP polymers to achieve sustained release of drug. The formulated batches were evaluated for physicochemical parameters and dissolution profiles as per pharmacopial methods. The physical parameters like weight variation, thickness, hardness, friability and assay of all formulations were evaluated. The results of formulated tablets complied with pharmacopoeial specifications and formulated combination F7 was well optimized and its stability data was found to be stable for three months at accelerated stability conditions at a temperature (40±2°C) and relative humidity 75±5% as per ICH norms.

Keywords: Naproxen, Tablets, Physiological parameters, Assay and Stability


Kadivar A, Kamalidehghan B, Javar HA, Davoudi ET, Zaharuddin ND, Sabeti B, et al., 2015. Formulation and In Vitro, In Vivo Evaluation of Effervescent Floating Sustained-Release Imatinib Mesylate Tablet. PLoS ONE, 10(6), 1-23.
Faiyaz Shakeel, Sushma, Talegaonkar, Farhan J, Mushir Ali. 2007. Design and evaluation of sustained release matrix once daily formulation of ramipril. Eur J Pharmaceutics and Biopharm. 66: 227-243.
Gibson M. 2004. Pharmaceutical Preformulation and formulation. A practical guide from candidate drug selection to commercial dosage form. 379-458.
Harun-Or-Rashid, Abul Kalam Lutful Kabir, Zakir Hossain Md, Abu Shara Shamsur Rouf. 2009. Design and formulation of once daily naproxen sustained release tablet matrix from Methocel-K15M CR and Methocel- K100M CR. Iranian Journal of Pharmaceutical Sciences, 5(4), 215-224.
Hokanson GC. 1994. A life cycle approach to the validation of analytical methods during Pharmaceutical product development, Part–II: Changes and the need for additional validation. Pharm Tech, 92-100.
John R Dyer. 2007. Infrared Spectroscopy. In: John R. Dyer. Editors. Applications of absorption spectroscopy of organic compounds. Eastern Economy Edition. Prentice – Hall of India. New Delhi. Pg. 22-57.
Khan GM, Meidan VK. 2007. Drug release kinetics from tablet matrices based on ethyl cellulose ether derivatives: A comparison between different formulations. Drug Develop Ind Pharm, 36, 627-39.
Lachmman L, Liberman HA, Konig JL. 1991. The theory and practice of Industrial Pharmacy. 3rd Edn. Vargheese Publishing House, Bombay. 430.
Loyd Allen. 2014. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. Lippincott Williams & Wilkins, USA.
Madan PL. 1985. Sustained-release drug delivery systems, part II: Preformulation considerations. Pharm Manu fact, 2, 41-45.
Maulik A Acharya, Mandev B Patel, Anil Bhandari. 2012. Formulation, Optimization and Evaluation of Spray Dried Microspheres Of Azithromycin Dihydrate. Int J Pharm Bio Sci, 3(3), 131-136.
Natanya Civijan. 2012. Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease. Chapter IX. John Wiley & Sons.
Robert M Silverstein, Francis X Webster. 2014. Infrared Spectrometry. In: Robert M. Silverstein editors. Spectrometric identification of organic compounds. 6th Ed. John Wiley and Sons. Inc. New York. Pg. 71-143.
Rogers JD, Kwan KC. 1979. Pharmacokinetic requirements for controlled-release dosage forms. In: John Urquhart, ed. Controlled-release
Pharmaceuticals. Academy of Pharmaceutical Sciences. American Pharmaceutical Association, 95-19.
Sandeep K, Mohanvarma M, Veerabhadhra Swamy P. 2013. Oral lipid-based drug delivery systems – an overview. Acta Pharm Sin B, 3(6), 361-372.
Sathish UB, Shravani, NG. Raghavendra Rao M. Srikanth Reddy B, Sanjeev Nayak. 2013. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences, 3(4), 258-269.
Shabaraya AR, Narayanacharyulu R. 2000. Design and evaluation of chitason matrix of metoprolol tartrate for sustained release. J Pharm Pharmaceutical Sci, 8 (1), 231-236
Vinay W, Santhosh P, Manjunth S Y, Rajmohommed M. 2011. Formulation and Evaluation of Naproxen Monolithic Sustained Release Matrix Tablet. J App Pharm, 4(3), 416-430.
Vree TB, Van Den Biggelaar-Martea M, Verwey-Van Wissen CP, Vree ML, Guelen PJ. 1993. The pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans. Effect of cimetidine. Br J Clin Pharmacol, 35(5), 467–472.
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Naidu K, K., Rao R , L., Kumar G, P., & S Priya A, S. (2019). Formulation and evaluation of Naproxen sustained release matrix tablet. Journal of Integral Sciences, 2(1), 6-16. Retrieved from
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