Dual role of high-fat diet in the development of diabetes: review
Abstract
A chronic metabolic disease that significantly affects people's health around the world is diabetes mellitus. High chronic fat intake is commonly associated with the development of insulin resistance, and hyperglycemia significantly alters the metabolism of lipids and carbohydrates. The objective of this review is to discuss the function of high-fat diet-induced diabetes mellitus, the mechanism at play, the various types of fats, and their impact on diabetes. DNA methylation, histone modifications, and an increase in the production of non-coding RNAs are some of the factors that might cause insulin resistance and lower the transcriptional activity of crucial genes for beta-cells. This meal pattern has been shown to improve insulin sensitivity and glycaemic control in persons with type 2 diabetes. High-fat diets have been related to better outcomes, but they can also increase insulin resistance and the beginning of type 2 diabetes.
Keywords:
Diabetes Mellitus, High-Fat Diet, Insulin Resistance, Insulin Sensitivity, T2D
References
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29. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. Diabetes. 2008 Jun 1;57(6):1470-81.
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2. Diabetes[Internet].Who.int.[cited2022Oct24].Availablefrom:https://www.who.int/health-topics/diabetes
3. Prasad M, Rajagopal P, Devarajan N, Veeraraghavan VP, Palanisamy CP, Cui B, Patil S, Jayaraman S. A comprehensive review on high-fat diet-induced diabetes mellitus: An epigenetic view. The Journal of Nutritional Biochemistry. 2022 Sep 1;107:109037.
4. Lozano I, Van der Werf R, Bietiger W, Seyfritz E, Peronet C, Pinget M, Jeandidier N, Maillard E, Marchioni E, Sigrist S, Dal S. High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications. Nutrition & metabolism. 2016 Dec;13:1-3.
5. Skovsø S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. Journal of diabetes investigation. 2014 Jul;5(4):349-58.
6. Yokomizo H, Inoguchi T, Sonoda N, Sakaki Y, Maeda Y, Inoue T, Hirata E, Takei R, Ikeda N, Fujii M, Fukuda K. Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice. American Journal of Physiology-Endocrinology and Metabolism. 2014 May 15;306(10):E1163-75.
7. Balakumar M, Raji L, Prabhu D, Sathishkumar C, Prabu P, Mohan V, Balasubramanyam M. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Molecular and cellular biochemistry. 2016 Dec;423:93-104.
8. Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids in health and disease. 2015 Dec;14(1):1-9.
9. Ullah R, Rauf N, Nabi G, Yi S, Yu-Dong Z, Fu J. Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus. Biomedicine & Pharmacotherapy. 2021 Oct 1;142:112012.
10. El-Moselhy MA, Taye A, Sharkawi SS, El-Sisi SF, Ahmed AF. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids. Food and Chemical Toxicology. 2011 May 1;49(5):1129-40.
11. Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomedicine & Pharmacotherapy. 2021 May 1;137:111315.
12. Barazzoni R, Gortan Cappellari G, Ragni M, Nisoli E. Insulin resistance in obesity: an overview of fundamental alterations. Eating and Weight disorders-studies on Anorexia, Bulimia and Obesity. 2018 Apr;23:149-57.
13. Dilworth L, Facey A, Omoruyi F. Diabetes mellitus and its metabolic complications: the role of adipose tissues. International journal of molecular sciences. 2021 Jul 16;22(14):7644.
14. Morio B, Fardet A, Legrand P, Lecerf JM. Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes. Nutrition reviews. 2016 Jan 1;74(1):33-47.
15. Risérus U, Willett WC, Hu FB. Dietary fats and prevention of type 2 diabetes. Progress in lipid research. 2009 Jan 1;48(1):44-51.
16. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.
17. Garonzi C, Forsander G, Maffeis C. Impact of fat intake on blood glucose control and cardiovascular risk factors in children and adolescents with type 1 diabetes. Nutrients. 2021 Jul 29;13(8):2625.
18. Sami W, Ansari T, Butt NS, Ab Hamid MR. Effect of diet on type 2 diabetes mellitus: A review. International journal of health sciences. 2017 Apr;11(2):65.
19. Murphy NE, Carrigan CT, Margolis LM. High-fat ketogenic diets and physical performance: a systematic review. Advances in Nutrition. 2021 Jan;12(1):223-33.
20. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
21. Mefferd CC, Bhute SS, Phan JR, Villarama JV, Do DM, Alarcia S, Abel-Santos E, Hedlund BP. A high-fat/high-protein, Atkins-type diet exacerbates Clostridioides (Clostridium) difficile infection in mice, whereas a high-carbohydrate diet protects. Msystems. 2020 Feb 11;5(1):10-128.
22. Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.
23. Othman MS, Khaled AM, Aleid GM, Fareid MA, Hameed RA, Abdelfattah MS, Aldin DE, Moneim AE. Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats. Environmental Science and Pollution Research. 2022 Oct;29(49):75043-56.
24. Lackey DE, Lazaro RG, Li P, Johnson A, Hernandez-Carretero A, Weber N, Vorobyova I, Tsukomoto H, Osborn O. The role of dietary fat in obesity-induced insulin resistance. American Journal of Physiology-Endocrinology and Metabolism. 2016 Dec 1;311(6):E989-97.
25. Tan BL, Norhaizan ME. Effect of high-fat diets on oxidative stress, cellular inflammatory response, and cognitive function. Nutrients. 2019 Oct 25;11(11):2579.
26. Roh, J., Hill, J.A., Singh, A.,Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
27. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
28. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071.
29. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. Diabetes. 2008 Jun 1;57(6):1470-81.
30. Zhang Q, Xiao X, Zheng J, Li M, Yu M, Ping F, Wang T, Wang X. A maternal high-fat diet induces DNA methylation changes that contribute to glucose intolerance in offspring. Frontiers in endocrinology. 2019 Dec 13;10:871.
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S, S. S., S, V. N., Sharma, D. K., Talukdar, A. J., Durga, P., Md, F., Ramakanth, M., Yojana, khatiwara, & Tasmiya , K. (2023). Dual role of high-fat diet in the development of diabetes: review. Journal of Integral Sciences, 6(2), 68-72. https://doi.org/10.37022/jis.v6i2.60
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