THERAPEUTIC POTENTIAL OF PHYTO CHEMICALS IN DIABETES CARE

David Kery Sikha

Sikha David Kery Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

The Therapeutic possibilities of plant based treatments the management of diabetetes of mechanism of the action. Diabetes mellitus is a common chronic Illness that serious danger at around the entire world. the properties of following plants are Alstonia scholaris, Annona squamosa, momordica charantia, cinnamon, fenugreek, Allium sativum, Neem, Ocimum sanctum, Ginseng berry, Aloe vera this data process are identify potiential phytoconstituents for treatment of diabetes mellitus.Herbal drugs are controlling diabetes safely effectively and different methods of action experiments on animals and humans. This review important discoveries and medicinal uses herbal treatment for diabetes WHO acknowledges the potiential of herbal drugs in treating different health issues, such as diabetes utilized conventional therapies. It is important to emphasize that herbal treatments are displayed potential diabetes they should be healthcare experts.herbal remedies have been traditionally treat to diabetes.the parts used test models hypoglycaemic [blood-sugar-lowering] active compounds of 20 plant species for 12 families crucial role of plant diabetes. The plants can delay complications from diabetes and metabolic imbalance.This review can attempt to cover for herbal plants like melon, fenugreek, ginseng cinnamon, garlic, gymnema managing blood glucose level due to saponin, terpenoids,flavonoids useful controlling diabetes descrption of gymnema gurmarin possible mechanism the gumarin helps manage taste buds receptors TIR1,TIR3 both β-cells and islets, PPARγ (peroxisome proliferator activated receptor gamma) β-cells is stimulated by gymnema. Plant culture methods gymnemic acid production Diabetes mellitus affecting over 537 million people poses health challenges prevalence and complications like Neuropathy, cardiovascular sylvestre, momordica charantia, trigonella, foenum-graecum cinnamomum veum, Aloe vera and clinical efficacy through results vary due to standardization issues.

Keywords: Diabetes mellitus, herbal medicine, antidiabetic plants, phytoconstituents, hypoglycemic activity, plant based therapy;, Gymnema sylvestre, momordica charantia, Aloe vera, blood glucose regulation, mechanism of action, metabolic disorder

References

1. Deshmukh P, Phuse A, Nimkar S, Ruikar D, Raut A. A review: anti-diabetic plants and its recent application. J Ayurvedic Herb Med. 2024;10(2):56-66. doi:10.31254/jahm.2024.10206.
2. Kumar S. Diabetes mellitus and allopathic medication increase the risk of cancer malignancy, but no side effect associated with the use of antidiabetic herbal medicine. Curr Res Diabetes Obes J. 2020;13(4). doi:10.19080/CRDOJ.2020.13.555868.
3. Alamgir ANM. Therapeutic Use of Medicinal Plants and Their Extracts. Vol. 1. Cham: Springer International Publishing; 2017. doi:10.1007/978-3-319-92387-1.
4. Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996;334(9):574-579. doi:10.1056/NEJM199602293340906.
5. Najmi A, Javed SA, Al Bratty M, Alhazmi HA. Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents. Molecules. 2022;27(2):349. doi:10.3390/molecules27020349.
6. Zhao XY, Zhang F, Pan W, Yang YF, Jiang XY. Clinical potentials of ginseng polysaccharide for treating gestational diabetes mellitus. World J Clin Cases. 2021;9(19):4959-4970. doi:10.12998/wjcc.v9.i19.4959.
7. Silva ML, Bernardo MA, Singh J, de Mesquita MF. Cinnamon as a complementary therapeutic approach for dysglycemia and dyslipidemia control in type 2 diabetes mellitus and its molecular mechanism of action: a review. Nutrients. 2022;14(13):2773. doi:10.3390/nu14132773.
8. Verma S, Gupta M, Popli H, Aggarwal G. Diabetes mellitus treatment using herbal drugs. Int J Phytomedicine. 2018;10(1):1-10.
9. Rao C. Evaluation of Antiulcer Activity of Picrasma Quassioides Bennett Aqueous Extract in Rodents. Vedic Research International Phytomedicine. 2013 Jan
10. Gindi S, Mehra T, Chandu BR, Boyina R, Dasari V. Antiurolithiatic and in vitro antioxidant activity of leaves of Ageratum conyzoides in rats. World J Pharm Pharm Sci. 2013;2(2):636-649.
11. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Trop J Pharm Res. 2011;10(4):489-495.
12. Dara SR. An overview of the use of natural indicators in acid-base titrations. UPI J Pharm Med Health Sci. 2024;4(2):29-35. doi:10.37022/jpmhs.v4i2.103.