ORGAN ON A CHIP INNOVATION IN PRECISION MEDICINE AND DRUG DESIGN

Reshma Shaik

Shaik Reshma Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

Organ-on-a-chip (OOC) technology is an advanced microengineered system that recreates the structure and function of human organs on a small, chip-based platform. By combining cell biology, biomaterials, engineering, and microfluidics, these devices imitate the natural environment of tissues, including fluid flow, mechanical forces, and cell interactions. Unlike traditional 2D cell cultures and animal testing, OOC systems provide more realistic physiological conditions while reducing cost and ethical concerns.Various organ models such as lung, liver, kidney, heart, intestine, skin, and brain have been successfully developed. These systems are widely used in drug screening, toxicology studies, disease modeling, pharmacokinetics, and personalized medicine research.

Keywords: Organ on chip technology, Drug screening, Microfluidics, Drug discovery, Human on a chip

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