Role of Herbs in the Treatment of Polycystic Ovarian Syndrome

Bhavitha Sree Gudhibandi

Gudhibandi Bhavitha Sree Priyadarshini Institute of pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur -522017, Andhra Pradesh, India.

Abstract

One of the most significant gynecological problems affecting women of reproductive age is polycystic ovarian syndrome (PCOS), a neuroendocrine metabolic disorder marked by irregular menstrual cycles. The secretory rate and complicated metabolism of estrogens and androgens are impaired in persons with PCOS. However, the limits of allopathic medications and the effective therapeutic effects of natural drugs draw PCOS patients to natural remedies. Ovulatory hyperandrogenism, which affects roughly 20–25% of women of reproductive age and is associated with a polycystic ovary shape, is believed to be one of the main reasons of infertility in women. Women with PCOS are more likely to experience elevated insulin levels, irregular periods, hypertension, and metabolic abnormalities. To treat PCOS, herbal remedies such as aloe vera, Tulasi, fennel, flax seeds, pumpkin seeds, and cinnamon are employed. Reduced insulin resistance, decreased ovarian weight, increased ovulation, and decreased hyperandrogenism are all brought on by herbal extracts that include phytoestrogens.

Keywords: Polycystic ovarian syndrome, infertility, insulin resistance, and hyperandrogenism

References

1. Abasian Z, Rostamzadeh A, Mohammadi M, Hosseini M, Rafieian-Kopaei M. A review on role of medicinal plants in polycystic ovarian syndrome: pathophysiology, neuroendocrine signaling, therapeutic status and future prospects. Middle East Fertility Society Journal. 2018 Dec 1;23(4):255-
2. Kolapudi RK, Kapudasi J, Koppula SB, Chandu B. Stem Cells Treatment for the Future Heart Diseases. Drug Invention Today. 2012 Jun 1;4(6).
3. Azziz R. Androgen excess disorders in women polycystic ovary syndrome and other disorders. Humana press; 2006.
4. Bency Baby T, Rani S, Remya K, Shebina Rasheed P, Azeem AK. Polycystic ovarian syndrome: Therapeutic potential of herbal remedies-A review. International Journal of Herbal Medicine. 2016;4(5):91-6.
5. Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA. Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. New England Journal of Medicine. 1989 Mar 2;320(9):559-65.
6. Begum GS, Shariff A, Ayman G, Mohammad B, Housam R, Khaled N. Assessment of risk factors for development of polycystic ovarian syndrome. diabetes. 2017;1(2).
7. Barkat MA, Goyal A, Barkat HA, Salauddin M, Pottoo FH, Anwer ET. Herbal medicine: clinical perspective and regulatory status. Combinatorial chemistry & high throughput screening. 2021 Nov 1;24(10):1573-82.
8. Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the siddis of Uttara Kannada district, Karnataka, India. Journal of ethnopharmacology. 1995 Jul 28;47(3):149-58.
9. Zeng LH, Rana S, Hussain L, Asif M, Mehmood MH, Imran I, Younas A, Mahdy A, Al-Joufi FA, Abed SN. Polycystic ovary syndrome: a disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies. Frontiers in Pharmacology. 2022 Jul 18;1318; 13:874914
10. Carmina E, Koyama T, Chang L, Stanczyk FZ, Lobo RA. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? American journal of obstetrics and gynecology. 1992 Dec 1;167(6):1807-12.
11. Ravella S, Angel M, Subramanian H, Thangavel N, Namballa M, Lokesh D, Mishra AK, Nagaraju GV. Navigating the Future of Cancer Diagnosis: A Comprehensive Review of Novel Approaches for Community-Based Treatment. future.;1:6.
12. Costa CT, Bevilaqua CM, Morais SM, Camurça-Vasconcelos AL, Maciel MV, Braga RR, Oliveira LM. Anthelmintic activity of Cocos nucifera L. on intestinal nematodes of mice. Research in veterinary science. 2010 Feb 1;88(1):101-3.
13. Armanini D, Castello R, Scaroni C, Bonanni G, Faccini G, Pellati D, Bertoldo A, Fiore C, Moghetti P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2007 Mar 1;131(1):61-7.
14. Elsheikh M, Murphy C. Polycystic ovary syndrome. Oxford University Press; 2008 Jan 3.
15. Felemban A, Tan SL, Tulandi T. Laparoscopic treatment of polycystic ovaries with insulated needle cautery: a reappraisal. Fertility and sterility. 2000 Feb 1;73(2):266-9.
16. Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian Journal of Medical Research. 2019 Oct 1;150(4):333-44. Ganie, M.A.; Vasudevan, V.; Wani, I.A.; Baba, M.S.; Arif, T.; Rashid, A. (2019).
17. Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian Journal of Medical Research. 2019 Oct 1;150(4):333-44.Goswami, P.K.; Khale, A. (2012). A Review. Int. J. Pharm. Phytopharm. Natural Remedies for Polycystic Ovarian Syndrome, 1, 396–402.