Anti-diabetic activity of Sida Cordifolia
Diabetes mellitus (DM) is one of the major diseases affecting the quality life of population around the world. There is no complete medication that controls the DM and its complications, in fact maintaining good health conditions. The traditional medicine which is principally based on medicinal plants (MPs) provides treatment for different diseases including DM and its complications. Many reports provide the evidence that different MPs possess anti-diabetic activity (ADA) and still many TMs are unexplored about their ADA. So, the current study aimed to evaluate the ADA of Sidacordifolia on Alloxan-induced diabetic mellitus in WISTAR albino rats. The phytochemical analysis of the extracts of S. cordifoliareveals the presences of different phytochemical components like sterols, terpenoids, alkaloids, flavanoids etc. The ethanolic and aqueous extracts showed dose dependent anti-diabetic activity as standard drug Glibenclamide. The extracts significantly controlled the blood glucose level, body weight loss and alteration in different lipid metabolic enzymes. The result of the present study provides the scientific confirmation to the traditional usage of S. cordifoliaand more research is going on to assess different pharmacological activities and isolation of bioactive molecules from it.
Bommer C, Sagalova V, Heesemann E et al., 2018. Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030. Diabetes Care,41, 963-970.
Choudhury H, Pandey M, Hua CK et al., 2017. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med, 8(3), 361‐376.
Doss A. 2009. Preliminary phytochemical screening of some Indian Medicinal Plants. Anc Sci Life, 29(2),12‐16.
Erejuwa OO, Nwobodo NN, Akpan JL et al., 2016. Nigerian Honey Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Rats. Nutrients, 8(3), 95.
Farsani MK, Amraie E, Kavian Pet al., 2016. Effects of aqueous extract of alfalfa on hyperglycemia and dyslipidemia in alloxan-induced diabetic Wistar rats. Interv Med Appl Sci, 8(3), 103‐108.
Franzotti EM, Santos CVF, Rodrigues HMSL et al., 2000. Anti-inflammatory, analgesic activity and acute toxicity of Sidacordifolia L. (Malva-branca). J Ethnopharmacol,72, 273-278.
Harris MI. 2004. Definition and classification of diabetes mellitus and the criteria for diagnosis: A fubdamental and clinical text. 3 rd ed. USA: Lippinctt Williams & Wilkins; 457-467.
Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. 2018. Medicinal plants: past history and future perspective. J HerbmedPharmacol, 7(1), 1-7
Kalaiarasan, Ahmed John S. 2011. Phytochemical screening and Antibacterial activity of Sidacordifolia Linn. (Malvaceae) leaf extract. Int J Medicobiol Res,1(2), 94-98.
Kushagra N, Mukesh Kumar Singh, Dhansay D et al., 2010. Anti-inflammatory activity and chemo profile of plants used in traditional medicine: a review. J Chem Pharm Res, 2(5), 122-130.
Mallikarjuna Rao T, Rajananda Swamy T, Ganga Rao B. 2018. Therapeutic Protection from Hepatic Injury and Chemical Constituents of Buchanania angustifoliaRoxb.Turk J Pharm Sci,15(2):117-124.
Marín-Peñalver JJ, Martín-Timón I, Sevillano-Collantes Cet al., 2016. Update on the treatment of type 2 diabetes mellitus. World J Diabetes, 7(17), 354‐395.
Modak M, Dixit P, Londhe Jet al., 2007. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin BiochemNutr, 40(3),163‐173.
Mohanraj K, Karthikeyan BS, Vivek-Ananth RP et al., 2018. IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics. Sci Rep, 8(1), 4329.
Nakahara Y, Ozaki K, Sano Tet al., 2014. Assessment of Alloxan-Induced Diabetic Rats as a Periodontal Disease Model Using a Selective Cyclooxygenase (COX)-2 Inhibitor. J ToxicolPathol. 27(2), 123‐129.
OECD Guideline for testing of Chemicals, 2001. Guideline 423: acute Oral Toxicity – Acute Toxic Class Method 2001.
Pang GM, Li FX, Yan Y et al., 2019. Herbal medicine in the treatment of patients with type 2 diabetes mellitus. Chin Med J (Engl),132(1), 78‐85.
Parhofer KG. 2015. Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes Metab J, 39(5), 353‐362.
Richter B, Bandeira-Echtler E, Bergerhoff Ket al., 2008. Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev, 2,CD006739.
Copyright © Author(s) retain the copyright of this article.