Anti-diabetic activity of Sida Cordifolia

Narasimha  Rao Y; Naveen  Babu K; Srikanth M

Narasimha Rao Y MedarametlaAnjammaMastanrao College of Pharmacy, Narasaraopet, Andhra Pradesh-522601, India
Naveen Babu K KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh-520008, India
Srikanth M MedarametlaAnjammaMastanrao College of Pharmacy, Narasaraopet, Andhra Pradesh-522601, India

Abstract

Diabetes mellitus (DM) is one of the major diseases affecting the quality life of population around the world. There is no complete medication that controls the DM and its complications, in fact maintaining good health conditions. The traditional medicine which is principally based on medicinal plants (MPs) provides treatment for different diseases including DM and its complications. Many reports provide the evidence that different MPs possess anti-diabetic activity (ADA) and still many TMs are unexplored about their ADA. So, the current study aimed to evaluate the ADA of Sidacordifolia on Alloxan-induced diabetic mellitus in WISTAR albino rats. The phytochemical analysis of the extracts of S. cordifoliareveals the presences of different phytochemical components like sterols, terpenoids, alkaloids, flavanoids etc. The ethanolic and aqueous extracts showed dose dependent anti-diabetic activity as standard drug Glibenclamide. The extracts significantly controlled the blood glucose level, body weight loss and alteration in different lipid metabolic enzymes. The result of the present study provides the scientific confirmation to the traditional usage of S. cordifoliaand more research is going on to assess different pharmacological activities and isolation of bioactive molecules from it.

Keywords: Diabetes mellitus, Traditional medicine, Medicinal Plants, Alloxan, Sida Cordifolia

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