A Review on Peptide Synthesis: Therapeutic agents, stabilizing agents and its applications
Abstract
Peptides are required as a part of health through their extended activity. Peptides are also purified because of their high target affinity. The synthesis includes both the conventional method and the microwave method among which microwave procedure is considered superior due to less reaction time and higher yeilds. The peptides were assessed for the inhibition activity of Urokinase plasminogen (UpA), coagulation factor XII, and also for the cytotoxicity and anti-microbial activity.
Keywords:
Peptides, Urokinase plasminogen, cytotoxicity, coagulation factor XI, purification
References
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22. De Luca C, Lievore G, Bozza D, Buratti A, Cavazzini A, Ricci A, Macis M, Cabri W, Felletti S, Catani M. Downstream processing of therapeutic peptides by means of preparative liquid chromatography. Molecules. 2021 Aug 3; 26(15):4688.
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24. Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, Wang X, Wang R, Fu C. Therapeutic peptides: Current applications and future directions. Signal Transduction and Targeted Therapy. 2022 Feb 14; 7(1):48
2. Muramatsu W, Yamamoto H. An economical approach for peptide synthesis via regioselective C–N bond cleavage of lactams. Chemical Science. 2022.
3. Sakhel B, Jayanthi S, Muhoza D, Okoto P, Kumar TK, Adams P. Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products. Journal of Chromatography B. 2021 May 15;1172:122627.
4. Aguilar-Toalá JE, Quintanar-Guerrero D, Liceaga AM, Zambrano-Zaragoza ML. Encapsulation of bioactive peptides: a strategy to improve the stability, protect the nutraceutical bioactivity and support their food applications. RSC advances. 2022;12(11):6449-58.
5. Deyle K, Kong XD, Heinis C. Phage selection of cyclic peptides for application in research and drug development. Accounts of Chemical Research. 2017 Aug 15;50(8):1866-74
6. Levy O. Antimicrobial proteins and peptides: anti‐infective molecules of mammalian leukocytes. Journal of leukocyte biology. 2004 Nov;76(5):909-25.
7. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
8. Lovejoy DA, Hogg DW, Dodsworth TL, Jurado FR, Read CC, and D’Aquila AL, Barsyte-Lovejoy D. Synthetic peptides as therapeutic agents: lessons learned from evolutionary ancient peptides and their transit across blood-brain barriers. Frontiers in Endocrinology. 2019 Nov 12;10:730.
9. Teerasak E, Thongararm P, Roytrakul S, Meesuk L, and Chumnanpuen P. Prediction of anticancer peptides against MCF-7 breast cancer cells from the peptidomes of Achatina fulica mucus fractions. Computational and structural biotechnology journal. 2016 Jan 1; 14:49-57.
10. Ford DJ, Duggan NM, Fry SE, Ripoll-Rozada J, Agten SM, Liu W, Corcilius L, Hackeng TM, van Oerle R, Spronk HM, Ashhurst AS. Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming. Journal of Medicinal Chemistry. 2021 May 28;64(11):7853-76.
11. Murray JK, Gellman SH. Parallel synthesis of peptide libraries using microwave irradiation. Nature Protocols. 2007 Mar;2(3):624-31.
12. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.
13. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.
14. Lovejoy DA, Hogg DW, Dodsworth TL, Jurado FR, Read CC, and D’Aquila AL, Barsyte-Lovejoy D. Synthetic peptides as therapeutic agents: lessons learned from evolutionary ancient peptides and their transit across blood-brain barriers. Frontiers in Endocrinology. 2019 Nov 12; 10:730.
15. Grange RM, Preedy ME, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA, Baliga RS, Hobbs AJ. Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature. British Journal of Pharmacology. 2022 Jun; 179(11):2443-59.
16. Singh, A., 2022. Hyperlipidemia in cardiovascular health and digestion. In Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health (pp. 141-150). Academic Press.
17. Chen L, Li X, Gao L, Fang W. Theoretical insight into the relationship between the structures of antimicrobial peptides and their actions on bacterial membranes. The Journal of PhysicalChemistryB.2015Jan22;119(3):850
18. Sørensen KK, Mishra NK, Paprocki MP, Mehrotra A, Jensen KJ. High‐Performance Reversed‐Phase Flash Chromatography Purification of Peptides and Chemically Modified Insulins. ChemBioChem. 2021 May 14; 22(10):1818-22.
19. Roh, J., Hill, J.A., Singh, A.,Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
20. De Luca C, Lievore G, Bozza D, Buratti A, Cavazzini A, Ricci A, Macis M, Cabri W, Felletti S, Catani M. Downstream processing of therapeutic peptides by means of preparative liquidchromatography.Molecules.2021Aug3;26(15):4688.
21. Sridhar K, Inbaraj BS, Chen BH. Recent developments on production, purification and biological activity of marine peptides. Food Research International. 2021 Sep 1; 147:110468.
22. De Luca C, Lievore G, Bozza D, Buratti A, Cavazzini A, Ricci A, Macis M, Cabri W, Felletti S, Catani M. Downstream processing of therapeutic peptides by means of preparative liquid chromatography. Molecules. 2021 Aug 3; 26(15):4688.
23. Sarabandi K, Gharehbeglou P, Jafari SM. Spray-drying encapsulation of protein hydrolysates and bioactive peptides: Opportunities and challenges. Drying Technology. 2020 Apr 3; 38(5-6):577-95.
24. Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, Wang X, Wang R, Fu C. Therapeutic peptides: Current applications and future directions. Signal Transduction and Targeted Therapy. 2022 Feb 14; 7(1):48
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How to Cite
T, Y. P., Khaleel, M., B, R., N, P. K., & Eain, N. U. (2023). A Review on Peptide Synthesis: Therapeutic agents, stabilizing agents and its applications. Journal of Integral Sciences, 6(1), 27-35. https://doi.org/10.37022/jis.v6i1.53
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