Study on Nootropic activity of Aegle marmelos L fruits
The present study carried out to evaluate the nootroptic protective effect of Aegle marmelos. Fresh A. marmelos fruits were used for methanolic extract preparation and used for the nootroptic protective activity on scopalamine induced amnesia in rats . The spatial memory was assessed by Morris water maze, and biomarker enzyme levels were estimated (acetylcholinesterase, malondialdehyde, Superoxide dismutase) to determine the nootropic activity. The outcome of current research suggest that methanolic extract of A. marmelos fruits significantly reversed the scopalamine induced spatial memory deficits and also inhibits the changed levels of biomarker enzymes due to scopalamine. In conclusion, the separation of the bioactive compounds from A. marmelos fruits can be used as an adjuvant medicine along with allopathic medicine in the treatment of cognitive disorders.
Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. 1961. A new and rapid colorimetric determination of acetyl-cholinesterase activity. Biochem Pharmacol. 7, 88-95.
Fibiger HC. 1990. Centrl cholinergic systems and memory. In: Squire LR, Lindenlaub E, editors. The biology of memory, Symposia Medica Hoechst 23, New York: Springer-Verlag, 381-98.
Kakkar P, Das B, Viswanathan PN. 1984. A modified spectrophotometric assay of superoxide dismutase. Ind J biochem Biophys, 21, 130-132.
Kaushik P Dhiman AK. 1999. Medicinal Plants and Raw Drugs of India, (Bishen Singh Mahendra Pal Singh, Dehradun), 623.
Kopelman, MD. 2002. Disorders of memory. Brain, 125 (10), 2152–90.
Loy CT, Schofield PR, Turner AM, Kwok JB. 2014. Genetics of dementia. Lancet, 383 (9919), 828–40.
Morris M. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth, 11, 47–60.
Narayan PY, Chanotia CS. 2009. Phytochemical and Pharmacological Profile of Leaves of Aegle Marmelos Linn. The Pharma Review, 144-150.
Ohkawa Η, Ohishi Ν, Yagi Κ. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-8.
Pamar CMK Kaushal. 1982. Aegle marmelos. p.1-5. In: Wild Fruits. Kalyanipublishers, New Delhi, India, 1-5.
Russo A, Borrelli F. 2005. Bacopa monniera, a reputed nootropic plant: An overview. Phytomed, 12, 305–17.
Sharma PC, Bhatia V, Bansal N, Sharma A. 2007. A review on bael tree. Natural Products Radianc, 6, 171−178.
Sharma PC, Yelne MB, Dennis TJ. 2005. Database on Medicinal plants used in Ayurveda and Sidha. Vol. 1. New Delhi: CCRAS, Dept. of AYUSH, Ministry of Health and Family Welfare, Govt. of India, 265–6.
Vijay BL, Krishna Murti, Upendra Kumar, Bhatt Sandipkumar P, Vipul G. 2010. Phytopharmacological Properties of Aegle Marmelos as A Potential Medicinal Tree: An Overview. Int J Pharm Sci Rev Res, 5(2), 67-72.
Visweswari G, Sivaprasad K, Lokanatha V, Rajendra W. 2010. The antiepileptic effect of Centella asiatica on the activities of Na+/K+, Mg 2+ and Ca2+-ATPases in rat brain during pentylenetetrazol-induced epilepsy. Indian J Pharmacol, 42, 82–6.